A tale of agriculturalists and hunter-gatherers: Exploring the thrifty genotype hypothesis in native South Americans.
Guillermo RealesDiego L RovarisVanessa C JacovasTábita HünemeierJosé R SandovalAlcibiades Salazar-GranaraDarío A DemarchiEduardo Tarazona-SantosAline B FelklMichele A SerafiniFrancisco M SalzanoRafael Bisso-MachadoDavid ComasVanessa R Paixão-CôrtesMaria-Catira BortoliniPublished in: American journal of physical anthropology (2017)
A complex scenario explains the observed frequencies of the tested markers in hunter-gatherers. Different factors, such as pleotropic alleles, rainforest selective pressures, and population dynamics, may be collectively shaping the observed genetic patterns. We conclude that although TGH seems a plausible hypothesis to explain part of the data, other factors may be important in our tested populations.