Convalescent Plasma for Covid-19-Induced ARDS in Mechanically Ventilated Patients.
Marianna ParlatoMichael PiagnerelliEric HosteNadia DardenneDavid GrimaldiIsabelle MichauxElisabeth De WaeleAlexander DumoulinPhilippe G JorensEmmanuel van der HauwaertFrédéric VallotStoffel LamoteWalter SwinnenNicolas De SchryverVincent FraipontNathalie de MeyNicolas DaubyNathalie LayiosJean-Baptiste MeslandGeert MeyfroidtMichel MoutschenVeerle CompernolleAndré GothotDaniel DesmechtMaria I Taveira da Silva PereiraMutien GariglianyTome NajdovskiAxelle BertrandAnne-Françoise DonneauPierre-François LaterrePublished in: The New England journal of medicine (2023)
The administration of plasma collected from convalescent donors with a neutralizing antibody titer of at least 1:160 to patients with Covid-19-induced ARDS within 5 days after the initiation of invasive mechanical ventilation significantly reduced mortality at day 28. This effect was mainly observed in patients who underwent randomization 48 hours or less after ventilation initiation. (Funded by the Belgian Health Care Knowledge Center; ClinicalTrials.gov number, NCT04558476.).
Keyphrases
- mechanical ventilation
- acute respiratory distress syndrome
- end stage renal disease
- healthcare
- newly diagnosed
- chronic kidney disease
- ejection fraction
- extracorporeal membrane oxygenation
- high glucose
- diabetic rats
- type diabetes
- coronary artery disease
- cardiovascular disease
- oxidative stress
- respiratory failure
- dengue virus
- stress induced