Spheroids derived from the stromal vascular fraction of adipose tissue self-organize in complex adipose organoids and secrete leptin.

Fermín RobledoLila González-HodarPablo TapiaAna-María FigueroaFernando EzquerVíctor A Cortés

Published in: Stem cell research & therapy (2023)

Newborn mice adipose SVF can be efficiently differentiated into leptin-secreting AS. Prolonged stimulation with insulin and rosiglitazone allows the formation of structurally complex adipose organoids able to respond to adrenergic lipolytic stimulation.

Keyphrases

adipose tissue
insulin resistance
high fat diet induced
high fat diet
type diabetes
bone marrow
metabolic syndrome
skeletal muscle