Does anti-HPA-1a affect birthweight in fetal and neonatal alloimmune thrombocytopenia?
Margaret McKelvySrishti TyagiEmilie Vander HaarMadhavi LakkarajaTim TomyStacy CorkeThea PalmerAmihai RottenstreichRick KapurHuiying ZhiDebra NewmanNina Schatz-SiemersJames B BusselPublished in: Pediatric blood & cancer (2024)
Untreated FNAIT-affected newborns were not small; however, treatment of FNAIT-affected pregnancies increased newborn birthweights despite corrections to account for other factors that might have influenced the results. High dose IVIG is believed to "block" FcRn and lower maternal anti-HPA-1a levels, and thus increase birthweights by reducing levels of maternal anti-HPA-1a and reducing placental villitis.