Reward history cues focal attention in whisker somatosensory cortex.

Prior reward is a potent cue for attentional capture, but the underlying neurobiology is largely unknown. In a novel whisker touch detection task, we show that mice flexibly shift attention between specific whiskers on a trial-by-trial timescale, guided by the recent history of stimulus-reward association. 2-photon calcium imaging and spike recordings revealed a robust neurobiological correlate of attention in somatosensory cortex (S1), boosting sensory responses to the attended whisker in L2/3 and L5, but not L4. Attentional boosting in L2/3 pyramidal cells was topographically precise and whisker-specific, and shifted receptive fields towards the attended whisker. L2/3 VIP interneurons were broadly activated by whisker stimuli, motion and arousal but did not carry a whisker-specific attentional signal, and thus did not mediate focal tactile attention. Thus, the history of stimuli and rewards in the recent past can dynamically engage local modulation in cortical sensory maps to guide flexible shifts in ongoing behavior.