Prevalence and Sequelae of Cryptococcal Antigenemia in Antiretroviral Therapy-Experienced Populations: An Evaluation of Reflex Cryptococcal Antigen Screening in Botswana.

William J HurtMark W TenfordeMooketsi MolefiHannah K MitchellThandi MiltonMartin S AzamaIrene GoerckeFredah MulengaNametso TlhakoKatlego TsholoTuhina SrivastavaTshepo B LeemeGodfrey SimoongaCharles MuthogaKwana LechiileMadisa MineJoseph N Jarvis

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

CrAg-positivity rates in an ART-experienced population were comparable to those seen in ART-naive populations. Repeat screening identified individuals who seroconverted to CrAg positivity and were at risk of cryptococcal disease. CrAg titers ≥1:80 can help identify the individuals at highest risk of death for more intensive management.

Keyphrases

antiretroviral therapy
hiv infected
human immunodeficiency virus
hiv infected patients
hiv positive
hiv aids
risk factors
hepatitis c virus