Higher latitude is significantly associated with an earlier age of disease onset in multiple sclerosis.
Chunrong TaoSteve Simpson YapIngrid van der MeiLeigh BlizzardEva HavrdovaDana HorakovaVahid ShaygannejadAlessandra LugaresiGuillermo IzquierdoMaria TrojanoPierre DuquetteMarc GirardFranois Grand'MaisonPierre GrammondRaed AlroughaniMurat TerziCelia Oreja-GuevaraSeyed Aidin SajediGerardo IulianoPatrizia SolaJeannette Lechner-ScottVincent Van PeschEugenio PucciRoberto BergamaschiMichael BarnettCristina RamoBhim SinghalDaniele LA SpitaleriMark SleeFreek VerheulRicardo Fernández BolañosMaria Pia AmatoEdgardo CristianoFranco GranellaSuzanne HodgkinsonMarcela FiolOrla GrayPamela McCombeMaria Laura SaladinoJosé Luis Sánchez MenoyoNeil ShueySteve VucicCameron ShawNorma DeriWalter Oleschko ArrudaHelmut ButzkuevenTim SpelmanBruce V Taylornull nullPublished in: Journal of neurology, neurosurgery, and psychiatry (2016)
An earlier AAO in higher latitude regions was found in this worldwide European-descent cohort and correlated inversely with variation in latitudinal UVR. These results suggest that environmental factors which act at the population level may significantly influence disease severity characteristics in genetically susceptible populations.
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