Genotype-Phenotype Characterization of Serial Mycobacterium tuberculosis Isolates in Bedaquiline-Resistant Tuberculosis.
Tyler S BrownLinrui TangShaheed Vally OmarLavania JosephGraeme MeintjesGary MaartensSean WassermanN Sarita ShahMaha R FarhatNeel R GandhiNazir IsmailJames C M BrustBarun MathemaPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2023)
BDQ-resistant TB can arise via multiple, overlapping processes, including transmission of strains with pre-existing resistance. Capturing the within-host diversity of these infections could potentially improve clinical diagnosis, population-level surveillance, and molecular diagnostic test development.