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Mesoporous Silica as a Drug Delivery System for Naproxen: Influence of Surface Functionalization.

Lukáš ŽidVladimir ZelenakMiroslav AlmášiAdriana ZeleňákováJaroslava SzücsováJozef BednarčíkMonika ŠulekováAlexander HudákLucia Váhovská
Published in: Molecules (Basel, Switzerland) (2020)
In this work we describe the relationship between surface modification of hexagonally ordered mesoporous silica SBA-15 and loading/release characteristics of nonsteroidal anti-inflammatory drug (NSAID) naproxen. Mesoporous silica (MPS) was modified with 3-aminopropyl, phenyl and cyclohexyl groups by grafting method. Naproxen was adsorbed into pores of the prepared MPS from ethanol solution using a solvent evaporation method. The release of the drug was performed in buffer medium at pH 2 and physiological solution at pH 7.4. Parent MPSs as well as naproxen loaded MPSs were characterized using physicochemical techniques such as nitrogen adsorption/desorption, thermogravimetric analysis (TG), Zeta potential analysis, Fourier transform infrared spectroscopy (FT-IR), and elemental analysis. The amount of naproxen released from the MPSs into the medium was determined by high-performance liquid chromatography (HPLC). It was shown that the adsorption and desorption characteristics of naproxen are dependent on the pH of the solution and the surface functionalization of the host.
Keyphrases
  • high performance liquid chromatography
  • drug delivery
  • ms ms
  • mass spectrometry
  • tandem mass spectrometry
  • solid phase extraction
  • risk assessment
  • high resolution
  • cancer therapy
  • liquid chromatography