Evaluation of between-, within- and day-to-day variation of coagulation measured by rotational thrombelastometry (ROTEM).
Petra Jilma-StohlawetzSusanne Fritsche-PolanzPeter QuehenbergerChristian SchörgenhoferJohann BartkoRobin RistlBernd JilmaPublished in: Scandinavian journal of clinical and laboratory investigation (2017)
To overcome the influence of diurnal variation, we recommend obtaining blood samples at specified times in the morning. The within-subject variation should be taken into account, when serial measurements of drug effects are required.