Revelation of the Electrochemical Chiral Recognition of l-Proline-Tuned Zr-MOFs.

Chirality plays an extremely important role in nature. In this work, a highly ordered and non-clustered crystalline material UiO-88-LP was synthesized by using l-proline (l-Pro)-tuning Zr-MOF and the solvothermal method, which was then modified on the glassy carbon electrode (GCE) to construct an electrochemical chiral interface for the recognition of tryptophan (Trp) configuration. UiO-88-LP composites were characterized by scanning electron microscopy, X-ray transmission diffraction, X-ray photoelectron spectroscopy, and Fourier transform infrared (FT-IR) spectroscopy. After optimization of the experimental conditions, redox peaks for l-Trp and d-Trp were clearly observed at the UiO-88-LP/GCE electrochemical sensing interface with a peak-to-current ratio ( I L / I D ) of 2.47. The peak current was positively correlated with the concentration of Trp. The electrochemical recognition behavior of l-Trp and d-Trp was investigated by differential pulse voltammetry. The electrochemical characterization showed that UiO-88-LP/GCE had an enantiomeric resolution of amino acids. The recognition mechanism showed that l-Pro entering the UiO-66 molecular cage provided a site for the system to be recognized, so the purpose of recognition was achieved. The relevant data provide theoretical support for the practical application of UiO-88-LP in electrochemical sensors.