Eplet mismatches associated with de novo donor-specific HLA antibody in pediatric kidney transplant recipients.
Olga CharnayaJune JonesMary Carmelle PhilogeneTeresa Po-Yu ChiangDorry L SegevAllan B MassieJacqueline M Garonzik WangPublished in: Pediatric nephrology (Berlin, Germany) (2021)
In a racially diverse population, only a subset of eplets was linked to antibody formation. Eplet load alone is not a sufficient surrogate for eplet immunogenicity. These findings illustrate the need to optimize precision in donor selection and allocation to improve long-term graft outcomes. Graphical Abstract A higher resolution version of the Graphical abstract is available as Supplementary information.