Irisin mediates beiging of adipose-derived mesenchymal stem cells through binding to TRPC3.

Chunling XueXuechun LiLi BaYamei ShenZhao SunJunjie GuYing YangQin HanRobert Chunhua Zhao

Published in: BMC biology (2022)

We found that TRPC3 is a key factor in irisin-induced beiging of MSCs, which may provide a new target pathway in addressing metabolic disorders. Our results additionally suggest that the interaction of irisin with TRPC3 may affect multiple tissues, including the brain.

Keyphrases

vascular smooth muscle cells
mesenchymal stem cells
high glucose
gene expression
diabetic rats
adipose tissue
insulin resistance
white matter
angiotensin ii
cerebral ischemia
oxidative stress
endothelial cells
blood brain barrier