The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders.
Patrick Miller-RhodesCuicui KongGurpreet S BahtPriyanka SaminathanRamona M RodriguizWilliam C WetselHarris A GelbardNiccolò TerrandoPublished in: Journal of neuroinflammation (2019)
These findings show that prophylactic URMC-099 treatment is sufficient to prevent surgery-induced microgliosis and cognitive impairment without affecting fracture healing. Together, these findings provide compelling evidence for the advancement of URMC-099 as a therapeutic option for PND.
Keyphrases
- cognitive decline
- mouse model
- cognitive impairment
- mild cognitive impairment
- drug induced
- minimally invasive
- liver failure
- coronary artery bypass
- high glucose
- diabetic rats
- respiratory failure
- single cell
- bipolar disorder
- oxidative stress
- coronary artery disease
- surgical site infection
- hip fracture
- percutaneous coronary intervention