High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership.

Philip M CarlucciJessica LiAndrea FavaKristina K DeonaraineDavid WofsyJudith A JamesChaim PuttermanBetty DiamondAnne DavidsonDerek M FineJose Monroy-TrujilloMohamed G AttaWade DeJagerJoel M GuthridgeKristin HaagDeepak A RaoMichael B BrennerJames A LedererWilliam ApruzzeseH Michael BelmontPeter M IzmirlyDevyn ZaminskiMing WuSean ConneryFernanda Payan-SchoberRichard FurieMaria Dall'EraKerry ChoDiane KamenKenneth KalunianJennifer AnolikJennifer BarnasMariko IshimoriMichael H Weismannull nullJill P BuyonMichelle Petri

Published in: Rheumatology (Oxford, England) (2022)

In this prospective study, three-quarters of patients with UPCR <1 had histology showing class III, IV, V or mixed with accompanying activity and chronicity despite an inactive sediment or normal serologies. These data support renal biopsy at thresholds lower than a UPCR of 1.

Keyphrases

systemic lupus erythematosus
heavy metals
risk factors
electronic health record
ultrasound guided
disease activity
fine needle aspiration
machine learning
artificial intelligence