DNA damage-induced immune response: Micronuclei provide key platform.

Published in: The Journal of cell biology (2017)

DNA damage-induced activation of the cytoplasmic DNA sensor cGAS influences the outcome of infections, autoinflammation, and cancer. Recent studies by Harding et al. (2017. Nature. http://dx.doi.org/10.1038/nature23470), Mackenzie et al. (2017. Nature. http://dx.doi.org/10.1038/nature23449), and Bartsch et al. (2017. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddx283) demonstrate a role for micronuclei formation in DNA damage-induced immune activation.

Keyphrases

dna damage
high glucose
oxidative stress
diabetic rats
immune response
endothelial cells
dna repair
drug induced
inflammatory response
single cell
induced pluripotent stem cells