Neuroaxonal and Glial Markers in Patients of the Same Age With Multiple Sclerosis.

Floor C LoonstraLodewijk R J de RuiterMarleen J A Koel-SimmelinkMenno Michiel SchoonheimEva M M StrijbisBastiaan MoraalFrederik BarkhofBernard M J UitdehaagCharlotte E TeunissenJoep Killestein

Published in: Neurology(R) neuroimmunology & neuroinflammation (2022)

In our cohort of patients of the same age, we report consistent correlations of sNfL and sGFAP with a range of metrics, especially in progressive MS, whereas contactin-1 was not related to clinical or MRI measures. This demonstrates the potential of sNfL and sGFAP as complementary biomarkers of neurodegeneration, reflected by disability, in progressive MS.

Keyphrases

multiple sclerosis
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
mass spectrometry
peritoneal dialysis
magnetic resonance imaging
ms ms
computed tomography
neuropathic pain