Coordination effect enabled palladium-catalyzed regioselective O -alkylation of 2-pyridones.
Zhiqiang LuYanzhi LiYi RuShujian YangChu HaoMengke ZuoRongkai JiaoWeilong WuYan ZhouHui YaoNianyu HuangYuqin FuPublished in: Chemical communications (Cambridge, England) (2022)
A novel tactic for the regioselective O -alkylation of 2-pyridones has been realized through palladium catalysis in moderate to high yields. The coordination effect between palladium and nitrogen on the pyridine ring plays a versatile role.
Keyphrases