Repair mechanism of Wuwei Fuzheng Yijing formula in di-2-ethylhexyl phthalate-induced sperm DNA fragmentation in mice.

Chenming ZhangShiqi WangZulong WangQi ZhangRubing ChenHao ZhangZhong HuaSicheng Ma

Published in: Pharmaceutical biology (2022)

WFY can repair sperm DNA damage caused by DEHP, and the mechanism may be related to PI3K/Akt and metabolic pathways, and Bhmt. This provides a new direction for using traditional Chinese medicine to prevent and repair reproductive system injury caused by pollutants.

Keyphrases

pi k akt
dna damage
signaling pathway
cell proliferation
oxidative stress
cell cycle arrest
drug induced
type diabetes
cell death
dna repair
escherichia coli
single molecule
cystic fibrosis
pseudomonas aeruginosa
insulin resistance
preterm infants
nucleic acid
wild type