Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy.

Katharina BuschMelanie KnyNora HuangTilman E KlassertMagdalena StockAlexander HahnSebastian GraegerMihail TodirasSibylle SchmidtBishwas ChamlingMichael WillenbrockStefan GroßDoreen BiedenwegArnd HeuserClaus ScheidereitChristian ButterStephan B FelixOliver OttoFriedrich C LuftHortense SlevogtJens Fielitz

Published in: Journal of cachexia, sarcopenia and muscle (2021)

IL-1β causes atrophy, impairs contractility and relaxation and decreases deformation of cardiomyocytes. Because NLRP3/IL-1β pathway inhibition attenuates cardiac atrophy and cardiomyopathy in sepsis, it could be useful to prevent septic cardiomyopathy.

Keyphrases

acute kidney injury
heart failure
intensive care unit
high glucose
septic shock
left ventricular
nlrp inflammasome
diabetic rats
single molecule
drug induced
smooth muscle