Enantioselective Synthesis of 3-Heterosubstituted-2-amino-1-ols by Sequential Metal-Free Diene Aziridination/Kinetic Resolution.
Irene Giménez-NuenoJoan GuaschIgnacio Funes-ArdoizFeliu MaserasM Isabel MatheuSergio CastillonYolanda DíazPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2019)
A general protocol for the enantioselective synthesis of 3-heterosubstituted-2-amino-1-ols was developed based on metal- free intramolecular regio- and stereoselective diene aziridination and regioselective opening. Kinetic resolution of the resulting (1'-NR1 R2 and 1'-SR)-4-oxazolidinones was performed using ABCs organocatalysts, expanding the application of this methodology.
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