Effects of Short-term Fasting on Ghrelin/GH/IGF-1 Axis in Healthy Humans: The Role of Ghrelin in the Thrifty Phenotype.

Tim HollsteinAlessio BasoloYigit UnluTakafumi AndoMary WalterJonathan KrakoffPaolo Piaggi

Published in: The Journal of clinical endocrinology and metabolism (2022)

Short-term fasting induced selective changes in the ghrelin/GH/IGF-1 axis, specifically a ghrelin-independent GH hypersecretion that did not translate into increased IGF-1 concentrations. Greater increase in ghrelin after 24-hour fasting was associated with greater decrease in 24hEE, indicating ghrelin as a novel biomarker of increased energy efficiency of the thrifty phenotype.

Keyphrases

growth hormone
blood glucose
insulin resistance
type diabetes
pi k akt
metabolic syndrome
drug induced
endothelial cells