SCAR: The high-prevalence antigen 013.008 in the Scianna blood group system.

Kshitij Srivastava Jasem AlbasriOmar M AlsuhaibaniHassan A AljasemMarina U BuenoTania AntonacciDonald R Branch Gregory Andrew Denomme Willy Albert Flegel

Published in: Transfusion (2020)

We characterized a high-prevalence antigen, with the proposed name "SCAR," which is the eighth antigen of the Scianna blood group system (proposed designation 013.008). Individuals homozygous for ERMAP:p.(Gln142Glu) protein variant can produce anti-SCAR. Although we did not observe any sign of hemolysis at this time, the anti-SCAR prompted a change of the treatment regimen. A review of the known reports indicated that all SC alloantibodies of sufficient titer should be considered capable of causing hemolysis.

Keyphrases

wound healing
risk factors
red blood cell
emergency department
protein protein
amino acid
combination therapy