Mesenchymal Stromal/Stem Cell Therapy Improves Salivary Flow Rate in Radiation-Induced Salivary Gland Hypofunction in Preclinical in vivo Models: A Systematic Review and Meta-Analysis.

Amanda-Louise Fenger CarlanderAnders Kierkegaard GundestrupPer Marcus JanssonBjarke FollinCecilie HoeegBirgitte Saima KousholtRasmus Tolstrup LarsenKathrine Kronberg JakobsenSusie RimborgAnne Fischer-NielsenChristian GrønhøjChristian von BuchwaldCharlotte Duch Lynggaard

Published in: Stem cell reviews and reports (2024)

In conclusion, this systematic review and meta-analysis showed a significant effect of MSC therapy for restoring SG functioning and regenerating SG tissue following radiotherapy in preclinical in vivo studies without serious adverse events. MSC therapy holds significant therapeutic potential in the treatment of radio-induced xerostomia, but comprehensive, randomized, clinical trials in humans are required to ascertain their efficacy in a clinical setting.

Keyphrases

radiation induced
stem cells
radiation therapy
cell therapy
bone marrow
early stage
high glucose
oxidative stress
mesenchymal stem cells
drug induced
endothelial cells
stress induced