The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney.
Zer VuePraveena PrasadHan LeKit NeikirkChanel HarrisEdgar Garza-LopezEric WangAlexandria MurphyBrenita JenkinsLarry VangEstevão ScudeseBryanna ShaoAshlesha KadamJianqiang ShaoAndrea G MarshallAmber CrabtreeBenjamin KirkAlice KohGenesis WilsonAshton OliverTaylor RodmanKinuthia KabugiHo-Jin KohQuinton SmithElma ZaganjorCelestine N WanjallaChandravanu DashChantell EvansMark A PhillipsDavid HubertOlujimi AjijolaAaron WhitesideYoung Do KooAndré KinderMert DemirciClaude F AlbrittonNelson WandiraSydney JamisonTaseer AhmedMohammad SaleemDhanendra TomarClintoria R WilliamsMariya T SweetwyneSandra A MurrayAnthonya CooperAnnet KiraboPooja JadiyaAnita M QuintanaPrasanna KattiDao Fu DaiMelanie R McReynoldsAntentor O HintonPublished in: bioRxiv : the preprint server for biology (2024)
Due to aging, the efficiency of kidney functions begins to decrease and the risk of kidney diseases may increase, but specific regulators of mitochondrial age-related changes are poorly explained. This study demonstrates the MICOS complex may be a target for mitigating age-related changes in mitochondria. The MICOS complex can be associated with oxidative stress and calcium dysregulation, which also arise in many kidney pathologies.