Multispectral Endoscopy with Light Gating for Early Cancer Detection.
Le QiuLei ZhangVladimir TurzhitskyUmar KhanYuri ZakharovKanchan KantekureEdward VitkinIrving ItzkanDouglas K PleskowMandeep SawhneyTyler M BerzinJeffrey D GoldsmithLev T PerelmanPublished in: IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society (2018)
This paper reports the application of endoscopic light scattering spectroscopy (LSS) with light gating to detect malignancies in the biliary and pancreatic ducts, and also reviews the application of endoscopic LSS for differentiating cystic neoplasms in the pancreas and detecting invisible dysplasia in Barrett's esophagus. Information about tissue structure within the superficial epithelium where malignancy starts is present within the spectra of reflected light. Fortunately, this component of the reflected light is not yet randomized. However multiple scattering randomizes the signal from the underlying connective tissue which obscures the desired signal. In order to extract diagnostic information from the reflected signal the multiple scattering component related to connective tissue scattering and absorption must be removed. This is accomplished using described here spatial or polarization gating implemented with endoscopically compatible fiber optic probes.
Keyphrases
- ultrasound guided
- health information
- high resolution
- single molecule
- oxidative stress
- magnetic resonance imaging
- small molecule
- emergency department
- monte carlo
- molecular dynamics
- young adults
- living cells
- magnetic resonance
- mass spectrometry
- small bowel
- phase ii
- quantum dots
- contrast enhanced
- endoscopic submucosal dissection