Neutrophil-specific STAT4 deficiency attenuates atherosclerotic burden and improves plaque stability via reduction in neutrophil activation and recruitment into aortas of Ldlr -/- mice.
W Coles KeeterAlina K MoriartyRachel AkersShelby MaMarion MussbacherJerry L NadlerElena V GalkinaPublished in: bioRxiv : the preprint server for biology (2023)
Our work indicates a pro-atherogenic role for STAT4-dependent neutrophil activation and how it contributes to multiple factors of plaque instability during advanced atherosclerosis in mice.