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A Peptide-Duocarmycin Conjugate Targeting the Thomsen-Friedenreich Antigen Has Potent and Selective Antitumor Activity.

Oliver Charles CartwrightAndrew Michael BeekmanMarco M D CominettiDavid A RussellMark Searcey
Published in: Bioconjugate chemistry (2020)
Solid-phase synthesis allowed the rapid generation of a peptide-drug conjugate. A peptide targeting the Thomsen-Friedenreich antigen (TFα) was conjugated to the alkylating subunit of the potent cytotoxin duocarmycin SA. The compound, containing a cathepsin B cleavable linker, was shown to be active and selective against TFα expressing tumor cell lines.
Keyphrases
  • cancer therapy
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  • anti inflammatory
  • emergency department
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