SEC61G overexpression and DNA amplification correlates with prognosis and immune cell infiltration in head and neck squamous cell carcinoma.

Tian-Zhu LuYiping ChenXiaochang GongQiaojuan GuoCanyang LinQingfeng LuoZiwei TuJianji PanJingao Li

Published in: Cancer medicine (2021)

SEC61G is overexpressed in HNSCC and is an independent prognostic factor for OS. SEC61G DNA amplification contributes to overexpression and poor outcome. Interestingly, SEC61G correlates with immune cell infiltration in HNSCC. These findings suggest that SEC61G is a potential broad-spectrum biomarker for prognosis in HNSCC.

Keyphrases

nucleic acid
prognostic factors
circulating tumor
cell proliferation
cell free
single molecule
risk assessment