Folate deficiency modifies the risk of CIN3+ associated with DNA methylation levels: a nested case-control study from the ASCUS-COL trial.
María Cecilia AgudeloSamuel AgudeloAttila T LorinczArianis Tatiana RamírezKelly Melisa CastañedaIsabel C Garcés-PalacioArnold H ZeaChandrika J PiyathilakeGloria Inéz Sánchez VásquezPublished in: European journal of nutrition (2023)
High methylation and deficient folate independently increased the risk of CIN3+ while deficient folate combined with high methylation was associated with a substantially elevated risk of CIN3+.