The role of socioeconomic status in the susceptibility to develop systemic lupus erythematosus in Mexican patients.
Norma Alicia Salgado-GaliciaSusana Hernández-DoñoDaniela Ruiz-GómezJuan Jakez-OcampoJoaquín ZúñigaGilberto Vargas-AlarconVíctor AcuñaMaría Teresa HernándezJosé Eduardo Márquez-GarcíaMaricela García-LechugaLuis LlorenteGuadalupe LimaCarlos Javier Pineda-VillaseñorNeng YuEdmond YunisJulio GranadosPublished in: Clinical rheumatology (2020)
These findings suggest that HLA class II DRB1 genes contribute to the susceptibility and protection to develop SLE differently depending on socioeconomic status. Due to this, the clinical manifestations vary among patients and it could be related to different admixture charge.Key Point• HLA class II DRB1 genes contribute to the susceptibility and protection to develop SLE differently depending on socioeconomic status.
Keyphrases
- systemic lupus erythematosus
- disease activity
- end stage renal disease
- genome wide
- ejection fraction
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- rheumatoid arthritis
- bioinformatics analysis
- genome wide identification
- gene expression
- transcription factor
- patient reported outcomes
- dna methylation
- patient reported