Matrix metalloproteinase-9 mediated shedding of syndecan-4 in glomerular endothelial cells.
Trine M ReineFrancesca LanzalacoOddrun KristiansenAnne Randi EngetSimon SatchellTrond G JenssenSvein O KolsetPublished in: Microcirculation (New York, N.Y. : 1994) (2019)
IL-1β but not hyperglycemia increases the shedding of syndecan-4 from GEnC in an MMP9-dependent manner. This provides a potential mechanism of GEnC damage in diabetes and other inflammatory conditions.