The selective 5-HT1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress.
Monika Głuch-LutwinKinga SałaciakAlicja GawalskaMarek JamrozikJoanna SniecikowskaAdrian Newman-TancrediMarcin KołaczkowskiKarolina PytkaPublished in: Psychopharmacology (2021)
Our studies showed that 5-HT1A receptor biased agonists such as F13714 and especially F15599, due to its less pronounced side effects, might have potential as fast-acting antidepressants.