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A novel sorbicillinoid compound as a potent anti-inflammation agent through inducing NLRP3 protein degradation.

Fangfang WangMeng ZhangMeng YuanZixuan XiaFengge YangSihao ZhangTengyu LinLian-Xiang LuoJinshan TangYouwei Zhang
Published in: British journal of pharmacology (2023)
This study identifies a novel compound JNUTS013 that inhibits inflammation through inducing NLRP3 protein degradation in vitro and in vivo, which not only supports the development of JNUTS013 as an anti-inflammation agent but also creates a new way for the treatment of inflammation by chemically inducing NLRP3 degradation.
Keyphrases
  • oxidative stress
  • binding protein
  • genome wide
  • protein protein
  • gene expression
  • dna methylation