Nusinersen mitigates neuroinflammation in severe spinal muscular atrophy patients.
Tommaso NuzzoRosita RussoFrancesco ErricoAdele D'AmicoAwet G TeweldeMariangela VallettaAmber HassanMichele TosiChiara PanicucciClaudio BrunoEnrico BertiniAngela ChamberyLivio PellizzoniAlessandro UsielloPublished in: Communications medicine (2023)
These findings highlight signatures of neuroinflammation that are specifically associated with severe SMA and the neuro-immunomodulatory effects of Nusinersen therapy.
Keyphrases
- end stage renal disease
- traumatic brain injury
- ejection fraction
- lipopolysaccharide induced
- newly diagnosed
- early onset
- chronic kidney disease
- lps induced
- cognitive impairment
- peritoneal dialysis
- prognostic factors
- cerebral ischemia
- gene expression
- inflammatory response
- bone marrow
- radiation therapy
- drug induced
- dna methylation
- subarachnoid hemorrhage