IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms.

Qi WuAi-Ling TianBei LiMarion LeducSabrina ForveillePeter HamleyWarren GallowayWei XiePeng LiuLiwei ZhaoShuai ZhangPan HuiFrank MadeoYi TuOliver KeppGuido Kroemer

Published in: Journal for immunotherapy of cancer (2022)

Altogether, these results suggest that IGF1R may constitute a novel and druggable therapeutic target for the treatment of cancer in conjunction with chemoimmunotherapies.

Keyphrases

papillary thyroid
squamous cell
cell death
pi k akt
lymph node metastasis
childhood cancer
endoplasmic reticulum stress
young adults
cell proliferation