TNM 8 staging system beyond p16: Double HPV/p16 status is superior to p16 alone in predicting outcome in oropharyngeal squamous cell carcinoma.
Christian von BuchwaldKathrine Kronberg JakobsenAmanda-Louise Fenger CarlanderSara TousChristian GrønhøjJacob H RasmussenJill BrooksMiren TabernaMarisa MenaFrancisca MoreyLaia BruniNikolaos BatisRuud H BrakenhoffC René LeemansRobert J Baatenburg de JongJens Peter KlussmannNora WuerdemannSteffen WagnerTina DalianisLinda MarklundHaïtham MirghaniAndrew SchacheJaqueline A JamesShao Hui HuangBrian O'SullivanPaul NankivellMartina A BroglieMarkus HoffmannElgar Susanne QuabiusLesley A AndersonStephanie G CraigLaia AlemanyHisham Mehannanull nullPublished in: European journal of cancer (Oxford, England : 1990) (2024)
The detection of HPV had a significant impact on survival probability for OPSCC patients with both p16-positive and p16-negative tumors. HPV testing should be integrated in cancer staging, especially in regions of low attributable fraction, alongside p16 evaluation to ensure a comprehensive assessment of prognosis.