Proteomic, biomechanical and functional analyses define neutrophil heterogeneity in systemic lupus erythematosus.
Kathleen R BashantAngel M AponteDavide RandazzoPaniz Rezvan SangsariAlexander J T WoodJack A BibbyErin E WestArlette VassalloZerai G MannaMartin P PlayfordNatasha JordanSarfaraz HasniMarjan GucekClaudia KemperAndrew Conway MorrisNicole Y MorganNicole ToepfnerJochen GuckNehal N MehtaEdwin R ChilversCharlotte SummersMariana J KaplanPublished in: Annals of the rheumatic diseases (2020)
Modulation of the neutrophil proteome and distinct changes in biophysical properties are observed alongside differences in neutrophil trafficking. SLE LDGs may be increasingly retained in microvasculature networks, which has important pathogenic implications in the context of lupus organ damage and small vessel vasculopathy.