A preclinical platform for assessing long-term drug efficacy exploiting mechanically tunable scaffolds colonized by a three-dimensional tumor microenvironment.
Elly De VlieghereKoen Van de VijverEva BlondeelNathan CarpentierRouba GhobeiraJarne PauwelsSebastian RiemannManon MinsartCharlotte FieuwsJohanna MestachAns BaeyensNathalie De GeyterCharlotte DebbautHannelore DenysBenedicte DescampsKathleen ClaesAnne VralJo Van DorpeKris GevaertBruno G De GeestWim CeelenSandra Van VlierbergheOlivier De WeverPublished in: Biomaterials research (2023)
The mechanically-tunable scaffolds colonized by a three-dimensional LGSOC allow long-term drug evaluation and can be considered as a valid alternative to reduce, replace and refine animal models in drug discovery.