Hierarchical lncRNA regulatory network in early-onset severe preeclampsia.

Haihua LiuZhijian WangYanjun LiQian ChenSijia JiangYue GaoJing WangYali ChiJie LiuXiaoli WuQiong ChenChaoqun XiaoMei ZhongChunlin ChenXinping Yang

Published in: BMC biology (2024)

Our results suggest that the differential expression of lncRNAs may perturb the lncRNA-TF-DEG hierarchical regulatory network, leading to the dysregulation of many genes involved in EOSPE. Our study provides a new strategy and a valuable resource for studying the mechanism underlying gene dysregulation in EOSPE patients.

Keyphrases

early onset
late onset
end stage renal disease
transcription factor
newly diagnosed
ejection fraction
chronic kidney disease
long non coding rna
genome wide
long noncoding rna
gene expression
pregnant women
copy number
genome wide identification
patient reported outcomes
genome wide analysis