Cannabidivarin completely rescues cognitive deficits and delays neurological and motor defects in male Mecp2 mutant mice.

Erica ZamberlettiMarina GabaglioFabiana PiscitelliJames S BrodieMarie Woolley-RobertsIsabella BarbieroMarco TramarinGiorgio BinelliNicoletta LandsbergerCharlotte Kilstrup-NielsenTiziana RubinoVincenzo Di MarzoDaniela Parolaro

Published in: Journal of psychopharmacology (Oxford, England) (2019)

CBDV administration exerts an enduring rescue of memory deficits in Mecp2 mutant mice, an effect that is associated with the normalization of BDNF, IGF-1 and rpS6 phosphorylation levels as well as CB1 and CB2 receptor expression. CBDV delays neurological defects but this effect is only transient.

Keyphrases

wild type
high fat diet induced
cerebral ischemia
traumatic brain injury
type diabetes
mouse model
working memory
signaling pathway
stress induced
protein kinase