Anti-IgE Effect of Small-Molecule-Compound Arctigenin on Food Allergy in association with a Distinct Transcriptome Profile.
Cao Ming ZhuoChangda LiuKamal D SrivastavaAdora LinChristopher A LazarskiLu WangAnish MaskeyYing SongXiaoke ChenNan YangLinda ZambranoRenna BushkoAnna Nowak-WegrzynAmanda CoxZhigang LiuWeihua HuangDavid DunkinMingsan MiaoXiu-Min LiPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2021)
Arctigenin markedly inhibited IgE production in U266 cells, peanut allergic murine model and PBMCs from allergic patients by down-regulating cell division, cell cycle-related genes and up-regulating anti-inflammatory factors.
Keyphrases
- cell cycle
- small molecule
- end stage renal disease
- single cell
- anti inflammatory
- cell proliferation
- ejection fraction
- newly diagnosed
- induced apoptosis
- chronic kidney disease
- prognostic factors
- cell cycle arrest
- genome wide
- rna seq
- cell therapy
- allergic rhinitis
- dna methylation
- patient reported outcomes
- bone marrow
- endoplasmic reticulum stress
- oxidative stress
- mesenchymal stem cells