Risk of Misleading Conclusions in Observational Studies of Time-to-Antibiotics and Mortality in Suspected Sepsis.

Theodore R PakJessica YoungCaroline S McKennaAnna AganLaura DelloStrittoMichael R FilbinSayon DuttaSameer S KadriEdward J SeptimusChanu RheeMichael Klompas

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2023)

Associations between time-to-antibiotics and mortality in sepsis are highly sensitive to analytic choices. Failure to adequately address these issues can generate misleading conclusions.

Keyphrases

cardiovascular events
acute kidney injury
intensive care unit
septic shock
risk factors
pulmonary embolism
cardiovascular disease
type diabetes
fluorescent probe
molecularly imprinted
liquid chromatography