Using NS1 Flavivirus Protein Microarray to Infer Past Infecting Dengue Virus Serotype and Number of Past Dengue Virus Infections in Vietnamese Individuals.
Tran Thi Nhu ThaoErwin de BruinHuynh Thi PhuongNguyen Ha Thao VyHenk-Jan van den HamBridget A WillsNguyen Thi Hanh TienHuynh Thi Le DuyenDinh The TrungStephen S WhiteheadMaciej F BoniMarion P G KoopmansHannah E ClaphamPublished in: The Journal of infectious diseases (2022)
Our results suggest that the microarray will be useful in seroepidemiological studies aimed at classifying the past infection history of individuals (past primary vs secondary and serotype of past primary infections) and thus inferring past transmission intensity of DENV in dengue-endemic settings. Future work to validate these models should be undertaken in different transmission settings and with samples later after infection.