Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal.

Paul J HarrisonElizabeth M TunbridgeAnnette C DolphinJeremy Hall

Published in: The British journal of psychiatry : the journal of mental science (2021)

We reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and outcomes. Third, research shows there is an opportunity for brain-selective CCBs, which are better suited to psychiatric indications.

Keyphrases

mental health
angiotensin converting enzyme
human health
genome wide
white matter
risk assessment
gene expression
resting state
multiple sclerosis
dna methylation
skeletal muscle
insulin resistance
transcription factor
blood brain barrier