Influence of NOD2 risk variants on hepatic encephalopathy and association with inflammation, bacterial translocation and immune activation.

Cristina RipollRobin GreinertPhilipp Alexander ReukenMatthias Christian ReichertSusanne N WeberYvonne HupferRaphaela StaltnerMagdalena Meier ClinienFrank LammertKaren Schmidt Alexander Zipprich

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

The presence of NOD2 risk variants in patients with cirrhosis is not associated with HE and has no marked impact on inflammation, BT, or immune activation. In contrast, the presence of HE was linked to ammonia, the acute phase response, and myeloid cell activation.

Keyphrases

oxidative stress
copy number
acute myeloid leukemia
early onset
stem cells
computed tomography
gene expression
cell therapy
bone marrow
room temperature
innate immune
genome wide