A longitudinal seroepidemiology study to evaluate antibody response to SARS-CoV-2 virus infection and vaccination in children in Calgary, Canada from July 2020 to April 2022: Alberta COVID-19 Childhood Cohort (AB3C) Study.

Emily J DoucetteJoslyn GrayKevin FonsecaCarmen L CharltonJamil N KanjiGraham TipplesSusan KuhnJessica DunnPayton SayersNicola E SymondsGuosong WuStephen B FreedmanJames D Kellner

Published in: PloS one (2023)

In our population, after the first peak of Omicron variant infections and introduction of COVID-19 vaccines for children, all vaccinated children, but just over one-half of unvaccinated children, had SARS-CoV-2 spike antibodies indicating infection and/or vaccination, highlighting the benefit of vaccination. It is not yet known whether a high proportion of seropositivity at the present time predicts sustained population-level protection against future SARS-CoV-2 transmission, infection or severe COVID-19 outcomes in children.

Keyphrases

sars cov
young adults
respiratory syndrome coronavirus
coronavirus disease
metabolic syndrome
early onset