Cancer Stem Cells-The Insight into Non-Coding RNAs.
Rut BrylOliwia PiwockaEmilia KawkaPaul E MozdziakBartosz KempistyAgnieszka Knopik-SkrockaPublished in: Cells (2022)
Since their initial identification three decades ago, there has been extensive research regarding cancer stem cells (CSCs). It is important to consider the biology of cancer stem cells with a particular focus on their phenotypic and metabolic plasticity, the most important signaling pathways, and non-coding RNAs (ncRNAs) regulating these cellular entities. Furthermore, the current status of therapeutic approaches against CSCs is an important consideration regarding employing the technology to improve human health. Cancer stem cells have claimed to be one of the most important group of cells for the development of several common cancers as they dictate features, such as resistance to radio- and chemotherapy, metastasis, and secondary tumor formation. Therapies which could target these cells may develop into an effective strategy for tumor eradication and a hope for patients for whom this disease remains uncurable.
Keyphrases
- cancer stem cells
- induced apoptosis
- human health
- cell cycle arrest
- signaling pathway
- risk assessment
- end stage renal disease
- current status
- chronic kidney disease
- prognostic factors
- climate change
- pi k akt
- cell death
- cell proliferation
- helicobacter pylori infection
- squamous cell carcinoma
- epithelial mesenchymal transition