Nationwide Turkish Cohort Study of Hypophosphatemic Rickets
Zeynep ŞiklarSerap TuranAbdullah BereketFirdevs BaşTülay GüranAzad AkberzadeAyhan AbaciKorcan DemirEce BöberMehmet Nuri ÖzbekCengiz KaraŞükran PoyrazoğluHasan Murat AydınAsli Derya Kardelen AlÖmer TarımErdal ErenNihal HatipogluMuammer BüyükinanNesibe AkyürekSemra CetinkayaElvan BayramoğluBeray Selver EklioğluSeyit Ahmet UçaktürkSaygın AbalıRuhsar Damla Gökşen ŞimşekYılmaz KorEdip Unalİhsan EsenRuken YıldırımOnur AkınAtilla ÇayırEmine DilekBirgül KirelAhmet AnikGönül ÇatliMerih BerberoğluPublished in: Journal of clinical research in pediatric endocrinology (2019)
HR treatment and follow-up is challenging and our results showed higher treatment doses were associated with NC without any change in serum phosphate levels, suggesting that giving higher doses led to increased phosphaturia, probably through stimulation of fibroblast growth factor 23. However, higher calcitriol doses could improve bone deformities. Safer and more efficacious therapies are needed.
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