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Expanding Clinical Phenotype and Novel Insights into the Pathogenesis of ICOS Deficiency.

Hassan AbolhassaniYasser M El-SherbinyGururaj ArumugakaniClive CarterStephen RichardsDylan LawlessPhilip WoodMatthew BucklandMarzieh HeydarzadehAsghar AghamohammadiSophie HambletonLennart HammarströmSiobhan O BurnsRainer DoffingerSinisa Savic
Published in: Journal of clinical immunology (2019)
ICOS deficiency is associated with defective T cell activation, with simultaneously enhanced stimulation of monocytes. The latter is likely to result from a lack of ICOS/ICOSL interaction which might be necessary to provide negative feedback which limits monocytes activation.
Keyphrases
  • dendritic cells
  • peripheral blood
  • replacement therapy