Expanding Clinical Phenotype and Novel Insights into the Pathogenesis of ICOS Deficiency.
Hassan AbolhassaniYasser M El-SherbinyGururaj ArumugakaniClive CarterStephen RichardsDylan LawlessPhilip WoodMatthew BucklandMarzieh HeydarzadehAsghar AghamohammadiSophie HambletonLennart HammarströmSiobhan O BurnsRainer DoffingerSinisa SavicPublished in: Journal of clinical immunology (2019)
ICOS deficiency is associated with defective T cell activation, with simultaneously enhanced stimulation of monocytes. The latter is likely to result from a lack of ICOS/ICOSL interaction which might be necessary to provide negative feedback which limits monocytes activation.